The Cathedral of Saint Mary of the Assumption, also known locally as Saint Mary's Cathedral, is the principal church of the Roman Catholic Archdiocese of San Francisco in San Francisco, California.

The cathedral was designed by local architects John Michael Lee, Paul A. Ryan and Angus McSweeney, collaborating with internationally known architects Pier Luigi Nervi and Pietro Belluschi — at the time, the Dean of the School of Architecture at MIT.